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User:Eneumann/Kinases

Canc Mol Genetics	Dom +
Canc Syndrome	Familial malignant melanoma +
Cancer Mut	Somatic +, Germline +
Chr	7 +, 12 +
Chr Band	7q21-q22 +, 12q14 +
Disease+Type	Cancer +, Inflammation +, Viral infection +, Cardiovascular +, Neurodegeneration +, Diabetes +, CNS +, Cognition +
GeneID	1021 +, 1019 +
Group	CMGC +
Label	p38 (alpha,beta,gamma,delta)  +, CDK6  +, CDK9  +, CDK2  +, GSK3alpha and GSK3beta  +, HIPK1  +, HIPK2  +, CDC2 (CDK1)  +, Erk5 (BMK1)  +, JNK3  +, JNK1  +, Dyrk1A  +, CDK4  +
Modification dateThis property is a special property in this wiki.	29 January 2008 15:01:22  +
Molecular+Basis	Overexpression +, Translocation +, Expression +, SNP +, Activated +, Loss-of-heterozygosity +, Splice-Change +, Gain-of-function Mutation +, Amplified +, Methylation +
Mut Type	T +, Mis +
Name	p38 (alpha,beta,gamma,delta)  +, CDK6  +, cyclin-dependent kinase 6  +, CDK9  +, CDK2  +, GSK3alpha and GSK3beta  +, HIPK1  +, HIPK2  +, CDC2 (CDK1)  +, Erk5 (BMK1)  +, JNK3  +, JNK1  +, Dyrk1A  +, CDK4  +, cyclin-dependent kinase 4  +
Notes	Overexpressed and/or disrupted by translocation in leukemias, lymphomas and other cancers and amplified in gliomas (Medline:9102208) and rodent cancers (Medline:12538879, 11719459). OMIM Gene Id: 603368. +, Expression elevated in many breast cancer cell lines. Null mice are resistant to carcinogens. Binds the p53 tumor suppressor (Medline:12702766). OMIM Gene Id: 608003. +, Possible tumor suppressor. Activates p53 in response to UV light, causing growth arrest and apoptosis. Required for cisplatin-induced apoptosis (Medline:14729469). Downregulated in breast and thyroid carcinomas. OMIM Gene Id: 606868. +, Candidate gene for some aspects of Down's Syndrome: located in DS critical region, and overexpression in mice gives rise to similar neurological abnormalities (Medline: 15198122). OMIM Gene Id: 600855. +
OMIM	602399 +, 603368 +, 603251 +, 116953 +, 605004 +, 608003 +, 606868 +, 116940 +, 602521 +, 602897 +, 601158 +, 600855 +, 123829 +
Origin	Http://eneumann.org/exhibit/kinase demo/kinases vu.html +
Symbol	CDK6 +, CDK4 +
Tissue	L +, E +
Transloc Partner	MLLT10 +
Tum Germ Mut	Melanoma +
Tum Soma Mut	ALL +
Type	Kinase +, Mutant Gene +
Uri	Http://eneumann.org/exhibit/kinase demo/item +

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